• Home
  • Browse
  • Search
  • Download
  • PSG Gateway
  • Help
  Basic Information
Ensembl ID
ENSG00000185158
      
Symbol LRRC37B
Description leucine rich repeat containing 37B [Source:HGNC Symbol;Acc:29070]
Status KNOWN
Biotype protein_coding
  Origination
Transcript
Peptide ENSP00000463513
Location chr17:30334891-30348875   
Branch 9
Branch View
Paralogues
Gene		 ENSG00000176809 (LRRC37A3)
Origination
Type		 DNA level Duplication likely
Paralogous
Alignment ?
Alignment
Details
Focal Gene FractionParalogues Gene FractionE-valueBit ScoreIdentity
61%36.2%0.0 75365.80%
  Selection
Population
Genomics
Analysis
TranscriptObserved # of
Nonsynonymous Substitution		Observed # of
Synonymous Substitution		  q  
ENST00000583342 1840.46
Domian EvolutionThe human gene encodes two LRRC37 domains, one LRR_8 domain and one LRRC37_ABC domain. Domain orders of chimpanzee orthologous gene and rhesus orthologous gene resemble human gene. Gibbon orthologous gene has one more LRRC37 domain. We checked the exon structure of gibbon orthologous gene and found this gene has two additional exons that lead to domain difference between this gene and human LRRC37B. Further blat and ChainNet analysis suggests this two exons and their adjacent sequences exit within the rhesus homologous gene but not human LRRC37B gene or chimpanzee homologous gene. We proposed gibbon homologous gene represent the ancestral state. Thus deletion of sequences occurred in the common ancestral lineage of human and chimpanzee could be an explanation.
  Phenotype Association
GWAS Studies NA
  Functional Genomics
Transcriptome
Profile
Proteomic
Profile
  Cross reference
Phylostratigraphy
ProteinHistorian
Literature

Last Modified at January 26, 2019
Copyright@ 2013-2023 by the ZhangLab colleagues, CAS,
Any Comments and suggestions mail to:zhanglabioz@gmail.com