Basic Information Ensembl ID ENSG00000204118        Symbol NAP1L6 Description nucleosome assembly protein 1-like 6 [Source:HGNC Symbol;Acc:31706] Status KNOWN Biotype protein_coding   Origination Transcript ENST00000373518 (branch 11) Peptide ENSP00000362617 Location chrX:72345876-72347919    Branch 11 Branch View Paralogues Gene ENSG00000186462 (NAP1L2) Origination Type DNA level Duplication likely Paralogous Alignment ? Alignment Details Focal Gene Fraction Paralogues Gene Fraction E-value Bit Score Identity 74.8% 17.4% 1e-35 115 67.50% Branch Test ? N S Ka Ks ω q? 158.7 54.3 0.249 0.745 0.333 8.4E-03   Selection Population Genomics Analysis Transcript Observed # of Nonsynonymous Substitution Observed # of Synonymous Substitution   q   ENST00000373518 4 1 0.88 Domian Evolution The human gene encodes one NAP domain. Domain order of chimpanzee homologous gene resembles human gene. Through protein level alignment we know the orangutan homologous gene gets truncated within a full domain coding exon. We proposed human gene and chimpanzee orthologous gene represent the ancestral state. Orangutan homologous gene experienced its specific changes. The orangutan homologous gene of human NAP1L6 is manually predicted. The orangutan homologous gene of human NAP1L6, ENSPPYG00000020469, is not ending with a stop codon in its coding sequence from Ensembl version 93.   Phenotype Association GWAS Studies NA   Functional Genomics Transcriptome Profile Proteomic Profile NA   Cross reference Phylostratigraphy ProteinHistorian Literature

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