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  Basic Information
Ensembl ID
ENSG00000088832
      
Symbol FKBP1A
Description FK506 binding protein 1A, 12kDa [Source:HGNC Symbol;Acc:3711]
Status KNOWN
Biotype protein_coding
  Origination
Transcript
Peptide ENSP00000409863
Location chr20:1352756-1373642   
Branch 0
Branch View
Created with Highcharts 4.1.5Chart context menuHumanChimpOrangutanGibbonRhesusMarmosetRabbitGuinea PigRatMouseHorseDogCowElephantOpossumPlatypusChickenZebra FinchLizardX.tropicalisSticklebackTetraodonZebrafish24681012141618Highcharts.com
Paralogues
Gene		 ENSG00000198225 (FKBP1C)
Origination
Type		 NA
Paralogous
Alignment ?
Created with Highcharts 4.1.5Chart context menuFocal Gene:FKBP1AProteinSequenceAlignmentParalogous Gene:FKBP1CHighcharts.com
Alignment
Details
Focal Gene FractionParalogues Gene FractionE-valueBit ScoreIdentity
100%100%7e-78 21595.37%
  Selection
Population
Genomics
Analysis
TranscriptObserved # of
Nonsynonymous Substitution		Observed # of
Synonymous Substitution		  q  
ENST00000381715 030.092
  Phenotype Association
GWAS Studies
Created with Highcharts 4.1.5Chart context menuNicotine dependence(smoking)GWASHighcharts.com
Tile size is proportional to negative log-transformed most significant
p-value of SNPs for each trait. For more details: click HERE
  Functional Genomics
Transcriptome
Profile
Created with Highcharts 4.1.5Chart context menuSee scatter plot of focal gene and its paralogues gene,for better visualization of correlation.Scatter Plotlog2( Mean FPKM + 1 )HPAFKBP1AFKBP1Cadrenalappendixbonemarrowbraincolonduodenumendometriumesophagusfatgallbladderheartkidneyliverlunglymphnodeovarypancreasplacentaprostatesalivaryglandskinsmallintestinespleenstomachtestisthyroidurinarybladder0246810Highcharts.com
Created with Highcharts 4.1.5Chart context menuSee distribution of focal gene and its paralogues geneDistributionlog2( FKBP1A FPKM + 1 )log2( FKBP1C FPKM + 1 )171 Samples, R = 0.26, P = 0.0006adrenalappendixbonemarrowbraincolonduodenumendometriumesophagusfatgallbladderheartkidneyliverlunglymphnodeovarypancreasplacentaprostatesalivaryglandskinsmallintestinespleenstomachtestisthyroidurinarybladder01234567890123456789Highcharts.com
Created with Highcharts 4.1.5Chart context menuSee scatter plot of focal gene and its paralogues gene, for better visualization of correlationScatter Plotlog2( Mean FPKM + 1 )GTExFKBP1AFKBP1CAdipose TissueAdrenal GlandBladderBloodBlood VesselBrainBreastCervix UteriColonEsophagusFallopian TubeFIBRBLSHeartKidneyLCLLiverLungMuscleNerveOvaryPancreasPituitaryProstateSalivary GlandSkinSmall IntestineSpleenStomachTestisThyroidUterusVagina0246810Highcharts.com
Created with Highcharts 4.1.5Chart context menuSee distribution of focal gene and its paralogues geneDistributionlog2( FKBP1A FPKM + 1 )log2( FKBP1C FPKM + 1 )1936 Samples, R = 0.21, P < 2e-10Adipose - SubcutaneousAdipose - Visceral (Omentum)Adrenal GlandArtery - AortaArtery - CoronaryArtery - TibialBladderBrain - AmygdalaBrain - Anterior cingulate cortex (BA24)Brain - Caudate (basal ganglia)Brain - Cerebellar HemisphereBrain - CerebellumBrain - CortexBrain - Frontal Cortex (BA9)Brain - HippocampusBrain - HypothalamusBrain - Nucleus accumbens (basal ganglia)Brain - Putamen (basal ganglia)Brain - Spinal cord (cervical c-1)Brain - Substantia nigraBreast - Mammary TissueCells - EBV-transformed lymphocytesCells - Transformed fibroblastsCervix - EctocervixCervix - EndocervixColon - SigmoidColon - TransverseEsophagus - Gastroesophageal JunctionEsophagus - MucosaEsophagus - MuscularisFallopian TubeHeart - Atrial AppendageHeart - Left VentricleKidney - CortexLiverLungMinor Salivary GlandMuscle - SkeletalNerve - TibialOvaryPancreasPituitaryProstateSkin - Not Sun Exposed (Suprapubic)Skin - Sun Exposed (Lower leg)Small Intestine - Terminal IleumSpleenStomachTestisThyroidUterusVaginaWhole Blood012345678910012345678910Highcharts.com
Created with Highcharts 4.1.5Before BirthAfter BirthChart context menuundefinedSummaryBy GenderundefinedSummaryBy StagesDevelopment Stage/AgeRPKMBrainSpanNCXHIPAMYSTRMDCB8 pcw10 pcw12 pcw14 pcw16 pcw18 pcw20 pcw22 pwc24 pcw26 pcw28 pcw30 pcw32 pcw34 pcw36 pcw38 pcw0 yrs2 yrs4 yrs6 yrs8 yrs10 yrs12 yrs14 yrs16 yrs18 yrs20 yrs22 yrs24 yrs26 yrs28 yrs30 yrs32 yrs34 yrs36 yrs38 yrs40 yrs0255075100125150175200225Highcharts.com
Created with Highcharts 4.1.5Before BirthAfter BirthChart context menuundefinedSummaryBy RegionundefinedSummaryBy StagesDevelopment Stage/AgeRPKMBrainSpanMale NCXFemale NCXMale Subcortical RegionFemale Subcortical Region8 pcw10 pcw12 pcw14 pcw16 pcw18 pcw20 pcw22 pwc24 pcw26 pcw28 pcw30 pcw32 pcw34 pcw36 pcw38 pcw0 yrs2 yrs4 yrs6 yrs8 yrs10 yrs12 yrs14 yrs16 yrs18 yrs20 yrs22 yrs24 yrs26 yrs28 yrs30 yrs32 yrs34 yrs36 yrs38 yrs40 yrs0100255075125150175Highcharts.com
Created with Highcharts 4.1.5Chart context menuundefinedSummaryBy RegionundefinedSummaryBy GenderRPKMBrainSpanEarly prenatal AEarly prenatal BEarly mid-prenatal AEarly mid-prenatal BLate mid-prenatalLate prenatalEarly infancyLate infancyEarly childhoodLate childhoodAdolescenceAdulthood0255075100125150175200225Highcharts.com
Proteomic
Profile
Created with Highcharts 4.1.5Chart context menuProtein Evidence Quantified by MaxQuantMaxQuantProtein Expression Quantificated By PFind20181219314216257365142017691431217411511151380121371038698410197601113590010203040FetalHeartFetalOvaryAdultCD8TcellsFetalGutFetalTestisAdultUrinarybladderFetalLiverAdultFrontalcortexAdultRectumAdultNKcellsQEVIRGWEEGVAQMSVGQRRGQTCVVHYTGMLEDGKGVQVETISPGDGRRGQTCVVHYTGMLEDGKKGWEEGVAQMSVGQRHighcharts.comOnly top 10 enriched tissues and top 5 abundant peptides
are shown in heatmap. For more details: click HERE
Created with Highcharts 4.1.5Chart context menuProtein Evidence Quantificated by PFindPFindProtein Expression Quantified by MaxQuant13161676102019509167608139607149206148401210450967801842506109200510152025FetalHeartFetalOvaryAdultRectumFetalLiverFetalTestisAdultUrinarybladderAdultProstateAdultPlateletsAdultCD8TcellsAdultNKcellsGVQVETISPGDGRTFPKGVQVETISPGDGRRGQTCVVHYTGMLEDGKRGQTCVVHYTGMLEDGKKGWEEGVAQMSVGQRHighcharts.comOnly top 10 enriched tissues and top 5 abundant peptides
are shown in heatmap. For more details: click HERE
  Cross reference
Phylostratigraphy
Created with Highcharts 4.1.5Chart context menuGlires, ScadentiaLaurasiatheriaAfrotheria, XenarthraMarsupialia, ProthotheriaSauropsidaAmphibiaActinopterygiiCyclostomata, ChondrichthyesUrochordataCephalochordataEchinodermataProtostomia, AceolmorphaCnidariaPoriferaChoanoflagellidaFungiOther eukaryotesArchea BacteriaPrimates02.557.51012.51517.52022.5Highcharts.com
ProteinHistorian
Created with Highcharts 4.1.5Chart context menuThis protein family database is similar to the other PPOD databases, but it is based on an OrthoMCL clustering of all proteins in the 48 species present in v7.0 of the PANTHER classification system.48 SpeciesTreeHumanRatMouseChickenZebrafishNematodeFruit FlyFission YeastBudding YeastArabidopsisDictyosteliumE. coliPPODv4_Jaccard + dolloPPODv4_Jaccard + wagner1.0PPODv4_MultiParanoid_dolloPPODv4_MultiParanoid + wagner1.0PPODv4_Nens_dolloPPODv4_Nens + wagner1.0PPODv4_OrthoMCL_dolloPPODv4_OrthoMCL + wagner1.0Highcharts.com
Created with Highcharts 4.1.5Chart context menuThe Princeton Protein Orthology Database (PPOD) provides several sets of protein family predictions for all proteins in the 12 genomes of the GO Reference Genome Project.12 SpeciesTreeHUMANPANTRMACMURATMOUSECANFABOVINMONDOORNANCHICKXENTRFUGRUDANRECIOINSTRPUCAEELCAEBRANOGADROMENEUCREMENIASHGOYEASTSCHPOARATHORYSJCHLREDICDIENTHIPLAYOTETTHLEIMAECOLIPSEA7GEOSLBRAJATHEMADEIRASTRCOAQUAECHLTAGLOVICHLAALEPINBACSUBACTNSULSOMETACPPODv4_PTHR7OrthoMCL + dolloPPODv4_PTHR7OrthoMCL + wagnerHighcharts.com
Literature

Last Modified at May 20, 2025
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