Basic Information Ensembl ID ENSG00000152926        Symbol ZNF117 Description zinc finger protein 117 [Source:HGNC Symbol;Acc:12897] Status KNOWN Biotype protein_coding   Origination Transcript ENST00000487644 (branch 7)ENST00000282869 (branch 8) Peptide ENSP00000282869 Location chr7:64438360-64451414    Branch 8 Branch View Paralogues Gene ENSG00000105750 (ZNF85) Origination Type DNA level Duplication Paralogous Alignment ? Alignment Details Focal Gene Fraction Paralogues Gene Fraction E-value Bit Score Identity 99.6% 81% 0.0 752 72.82%   Selection Population Genomics Analysis Transcript Observed # of Nonsynonymous Substitution Observed # of Synonymous Substitution   q   ENST00000282869 37 15 0.88 Orthologous Evolutionary Estimation ? N S Ka Ks ω p q 886.1 259.9 0.08 0.171 0.452 1.21E-03 9.83E-05 Domian Evolution The human gene encodes twelve zf-C2H2 domains. The domain orders of all homologous gene differ from human ZNF117 and differ from each other when it comes to zf-C2H2 domain. We do not intend to propose an ancestral state but speculate complex and multiple domain gain or deletion events lead to diverse zf-C2H2 domains orders among homologous ZNF117 genes. The orangutan homologous gene and marmoset homologous gene of human ZNF117 both have one KRAB domain. We propose they represent the ancestral state when it comes to KRAB domain. Through exon level alignment we know a PTC within the KRAB coding exon leads to the loss of KRAB domain in both human and chimpanzee. A 10 bp deletion within the KRAB coding exon leads to the loss of KRAB domain in the gibbon lineage. The KRAB coding exon sequence exists and is complete in rhesus homologous gene but is not annotated in Ensembl version 93. The orangutan homologous gene of human ZNF117, ENSPPYG00000017531, might have some annotation problems since Ensembl version 93 even annotates one 4 bp and one 3 bp non-canonical intron within the gene.   Phenotype Association GWAS Studies NA   Functional Genomics Transcriptome Profile Proteomic Profile NA   Cross reference Phylostratigraphy ProteinHistorian Literature

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