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  Basic Information
Ensembl ID
ENSG00000154537
      
Symbol FAM27C
Description family with sequence similarity 27, member C [Source:HGNC Symbol;Acc:23668]
Status KNOWN
Biotype protein_coding
  Origination
Transcript
Peptide ENSP00000366765
Location chr9:44990314-44991483   
Branch 13
Branch View
Created with Highcharts 4.1.5Chart context menuHumanChimpOrangutanGibbonRhesusMarmosetRabbitGuinea PigRatMouseHorseDogCowElephantOpossumPlatypusChickenZebra FinchLizardX.tropicalisSticklebackTetraodonZebrafish24681012141618Highcharts.com
Paralogues
Gene		 ENSG00000182368 (FAM27A)
Origination
Type		 DNA level Duplication
Paralogous
Alignment ?
Created with Highcharts 4.1.5Chart context menuFocal Gene:FAM27CProteinSequenceAlignmentParalogous Gene:FAM27AHighcharts.com
Alignment
Details
Focal Gene FractionParalogues Gene FractionE-valueBit ScoreIdentity
100%100%2e-49 139100.00%
Paralogous
Pairwise
Estimation ?
NSKaKsωq?
150.950.100.0210.0010.28
  Selection
Population
Genomics
Analysis
TranscriptObserved # of
Nonsynonymous Substitution		Observed # of
Synonymous Substitution		  q  
ENST00000377542 000.88
  Phenotype Association
GWAS Studies NA
  Functional Genomics
Transcriptome
Profile
Created with Highcharts 4.1.5Chart context menuSee scatter plot of focal gene and its paralogues gene,for better visualization of correlation.Scatter Plotlog2( Mean FPKM + 1 )HPAFAM27CFAM27Aadrenalappendixbonemarrowbraincolonduodenumendometriumesophagusfatgallbladderheartkidneyliverlunglymphnodeovarypancreasplacentaprostatesalivaryglandskinsmallintestinespleenstomachtestisthyroidurinarybladder00.050.10.150.2Highcharts.com
Created with Highcharts 4.1.5Chart context menuSee distribution of focal gene and its paralogues geneDistributionlog2( FAM27C FPKM + 1 )log2( FAM27A FPKM + 1 )171 Samples, R = -0.1, P = 0.2044adrenalappendixbonemarrowbraincolonduodenumendometriumesophagusfatgallbladderheartkidneyliverlunglymphnodeovarypancreasplacentaprostatesalivaryglandskinsmallintestinespleenstomachtestisthyroidurinarybladder00.511.522.533.544.555.5600.511.522.533.544.555.56Highcharts.com
Created with Highcharts 4.1.5Chart context menuSee scatter plot of focal gene and its paralogues gene, for better visualization of correlationScatter Plotlog2( Mean FPKM + 1 )GTExFAM27CFAM27AAdipose TissueAdrenal GlandBladderBloodBlood VesselBrainBreastCervix UteriColonEsophagusFallopian TubeFIBRBLSHeartKidneyLCLLiverLungMuscleNerveOvaryPancreasPituitaryProstateSalivary GlandSkinSmall IntestineSpleenStomachTestisThyroidUterusVagina00.020.040.060.08Highcharts.com
Created with Highcharts 4.1.5Chart context menuSee distribution of focal gene and its paralogues geneDistributionlog2( FAM27C FPKM + 1 )log2( FAM27A FPKM + 1 )1936 Samples, R = -0.07, P = 0.003Adipose - SubcutaneousAdipose - Visceral (Omentum)Adrenal GlandArtery - AortaArtery - CoronaryArtery - TibialBladderBrain - AmygdalaBrain - Anterior cingulate cortex (BA24)Brain - Caudate (basal ganglia)Brain - Cerebellar HemisphereBrain - CerebellumBrain - CortexBrain - Frontal Cortex (BA9)Brain - HippocampusBrain - HypothalamusBrain - Nucleus accumbens (basal ganglia)Brain - Putamen (basal ganglia)Brain - Spinal cord (cervical c-1)Brain - Substantia nigraBreast - Mammary TissueCells - EBV-transformed lymphocytesCells - Transformed fibroblastsCervix - EctocervixCervix - EndocervixColon - SigmoidColon - TransverseEsophagus - Gastroesophageal JunctionEsophagus - MucosaEsophagus - MuscularisFallopian TubeHeart - Atrial AppendageHeart - Left VentricleKidney - CortexLiverLungMinor Salivary GlandMuscle - SkeletalNerve - TibialOvaryPancreasPituitaryProstateSkin - Not Sun Exposed (Suprapubic)Skin - Sun Exposed (Lower leg)Small Intestine - Terminal IleumSpleenStomachTestisThyroidUterusVaginaWhole Blood012345678012345678Highcharts.com
Created with Highcharts 4.1.5Before BirthAfter BirthChart context menuundefinedSummaryBy GenderundefinedSummaryBy StagesDevelopment Stage/AgeRPKMBrainSpanNCXHIPAMYSTRMDCB8 pcw10 pcw12 pcw14 pcw16 pcw18 pcw20 pcw22 pwc24 pcw26 pcw28 pcw30 pcw32 pcw34 pcw36 pcw38 pcw0 yrs2 yrs4 yrs6 yrs8 yrs10 yrs12 yrs14 yrs16 yrs18 yrs20 yrs22 yrs24 yrs26 yrs28 yrs30 yrs32 yrs34 yrs36 yrs38 yrs40 yrs-0.02500.0250.050.0750.10.1250.150.1750.2Highcharts.com
Created with Highcharts 4.1.5Before BirthAfter BirthChart context menuundefinedSummaryBy RegionundefinedSummaryBy StagesDevelopment Stage/AgeRPKMBrainSpanMale NCXFemale NCXMale Subcortical RegionFemale Subcortical Region8 pcw10 pcw12 pcw14 pcw16 pcw18 pcw20 pcw22 pwc24 pcw26 pcw28 pcw30 pcw32 pcw34 pcw36 pcw38 pcw0 yrs2 yrs4 yrs6 yrs8 yrs10 yrs12 yrs14 yrs16 yrs18 yrs20 yrs22 yrs24 yrs26 yrs28 yrs30 yrs32 yrs34 yrs36 yrs38 yrs40 yrs-0.02500.0250.050.0750.10.1250.150.175Highcharts.com
Created with Highcharts 4.1.5Chart context menuundefinedSummaryBy RegionundefinedSummaryBy GenderRPKMBrainSpanEarly prenatal AEarly prenatal BEarly mid-prenatal AEarly mid-prenatal BLate mid-prenatalLate prenatalEarly infancyLate infancyEarly childhoodLate childhoodAdolescenceAdulthood-0.0500.050.10.150.20.250.30.350.4Highcharts.com
Proteomic
Profile		 NA
  Cross reference
Phylostratigraphy
Created with Highcharts 4.1.5Chart context menuGlires, ScadentiaLaurasiatheriaAfrotheria, XenarthraMarsupialia, ProthotheriaSauropsidaAmphibiaActinopterygiiCyclostomata, ChondrichthyesUrochordataCephalochordataEchinodermataProtostomia, AceolmorphaCnidariaPoriferaChoanoflagellidaFungiOther eukaryotesArchea BacteriaPrimates02.557.51012.51517.52022.5Highcharts.com
ProteinHistorian
Created with Highcharts 4.1.5Chart context menuThis protein family database is similar to the other PPOD databases, but it is based on an OrthoMCL clustering of all proteins in the 48 species present in v7.0 of the PANTHER classification system.48 SpeciesTreeHumanRatMouseChickenZebrafishNematodeFruit FlyFission YeastBudding YeastArabidopsisDictyosteliumE. coliPPODv4_Jaccard + dolloPPODv4_Jaccard + wagner1.0PPODv4_MultiParanoid_dolloPPODv4_MultiParanoid + wagner1.0PPODv4_Nens_dolloPPODv4_Nens + wagner1.0PPODv4_OrthoMCL_dolloPPODv4_OrthoMCL + wagner1.0Highcharts.com
Created with Highcharts 4.1.5Chart context menuThe Princeton Protein Orthology Database (PPOD) provides several sets of protein family predictions for all proteins in the 12 genomes of the GO Reference Genome Project.12 SpeciesTreeHUMANPANTRMACMURATMOUSECANFABOVINMONDOORNANCHICKXENTRFUGRUDANRECIOINSTRPUCAEELCAEBRANOGADROMENEUCREMENIASHGOYEASTSCHPOARATHORYSJCHLREDICDIENTHIPLAYOTETTHLEIMAECOLIPSEA7GEOSLBRAJATHEMADEIRASTRCOAQUAECHLTAGLOVICHLAALEPINBACSUBACTNSULSOMETACPPODv4_PTHR7OrthoMCL + dolloPPODv4_PTHR7OrthoMCL + wagnerHighcharts.com
Literature

Last Modified at May 20, 2025
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