Basic Information Ensembl ID ENSG00000160229        Symbol ZNF66 Description zinc finger protein 66 [Source:HGNC Symbol;Acc:13135] Status KNOWN Biotype protein_coding   Origination Transcript ENST00000360204 (branch 9)ENST00000594534 (branch 9)ENST00000344519 (branch 9)ENST00000425625 (branch 9) Peptide ENSP00000459573 Location chr19:20973438-20991922    Branch 9 Branch View Paralogues Gene ENSG00000237440 (ZNF737) Origination Type DNA level Duplication likely Paralogous Alignment ? Alignment Details Focal Gene Fraction Paralogues Gene Fraction E-value Bit Score Identity 93.4% 99.8% 0.0 933 81.50%   Selection Population Genomics Analysis Transcript Observed # of Nonsynonymous Substitution Observed # of Synonymous Substitution   q   ENST00000425625 45 10 0.17 Domian Evolution The human gene encodes a protein containing one KRAB domain and fifteen zf-C2H2 domains. Domain orders of chimpanzee homologous gene and gibbon homologous gene resemble human gene. Rhesus homologous gene differs from human gene. Either gain of sequences in rhesus lineage or loss of sequences in the common ancestral lineage of human, chimpanzee and gibbon could be an explanation.   Phenotype Association GWAS Studies NA   Functional Genomics Transcriptome Profile Proteomic Profile   Cross reference Phylostratigraphy ProteinHistorian Literature

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