Basic Information Ensembl ID ENSG00000167232        Symbol ZNF91 Description zinc finger protein 91 [Source:HGNC Symbol;Acc:13166] Status KNOWN Biotype protein_coding   Origination Transcript ENST00000595533 (branch 9)ENST00000397082 (branch 9)ENST00000300619 (branch 9)ENST00000593341 (branch 9)ENST00000599281 (branch 9)ENST00000599743 (branch 9)ENST00000596989 (branch 9)ENST00000597458 (branch 10)ENST00000593292 (branch 10)ENST00000593645 (branch 10)ENST00000595893 (branch 12)ENST00000596528 (branch 12) Peptide ENSP00000380272 Location chr19:23542205-23578248    Branch 9 Branch View Paralogues Gene ENSG00000196350 (ZNF729) Origination Type DNA level Duplication Paralogous Alignment ? Alignment Details Focal Gene Fraction Paralogues Gene Fraction E-value Bit Score Identity 97.1% 98.5% 0.0 1713 70.35%   Selection Population Genomics Analysis Transcript Observed # of Nonsynonymous Substitution Observed # of Synonymous Substitution   q   ENST00000599743 12 3 0.63 Population Statistics iHS_CEU ? iHS_YRI ? 1.8539 2.46982 Orthologous Evolutionary Estimation ? N S Ka Ks ω p q 2417.4 699.6 0.06 0.128 0.479 6.31E-06 6.98E-07 Domian Evolution The human gene encodes a protein containing one KRAB domain and thirty-four zf-C2H2 domains. Domain orders of chimpanzee homologous gene resembles human gene. Orangutan homologous gene and gibbon homologous gene resembles each other but both differ from human gene. We proposed they represent the ancestral state. Thus human and chimpanzee experienced their specific changes in their common ancestral lineage. Rhesus homologous gene differs from orangutan or gibbon. Either gain of sequences in rhesus lineage or deletion of sequences in the common ancestral lineage of orangutan and gibbon could be an explanation. The chimpanzee homologous gene and orangutan homologous gene human ZNF91 is manually predicted. The gibbon homologous gene human ZNF91, ENSNLEG00000026775, only exist before Ensemble version 90.   Phenotype Association GWAS Studies NA   Functional Genomics Transcriptome Profile Proteomic Profile NA   Cross reference Phylostratigraphy ProteinHistorian Literature Description Branch Literature catarrhine 9 Jacobs et al., 2014

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