Basic Information Ensembl ID ENSG00000197008        Symbol ZNF138 Description zinc finger protein 138 [Source:HGNC Symbol;Acc:12922] Status KNOWN Biotype protein_coding   Origination Transcript ENST00000307355 (branch 9)ENST00000494380 (branch 9)ENST00000440155 (branch 9)ENST00000440598 (branch 9)ENST00000437743 (branch 9)ENST00000430838 (branch 9)ENST00000359735 (branch 9)ENST00000397136 (branch 9) Peptide ENSP00000380325 Location chr7:64275995-64294026    Branch 9 Branch View Paralogues Gene ENSG00000196247 (ZNF107) Origination Type DNA level Duplication Paralogous Alignment ? Alignment Details Focal Gene Fraction Paralogues Gene Fraction E-value Bit Score Identity 79.9% 32.6% 3e-136 398 72.94% Paralogous Pairwise Estimation ? N S Ka Ks ω q? 595 170 0.16 0.243 0.641 0.44   Selection Population Genomics Analysis Transcript Observed # of Nonsynonymous Substitution Observed # of Synonymous Substitution   q   ENST00000359735 16 3 0.35 Domian Evolution The human gene encodes one KRAB domain and five zf-C2H2 domains. The zf-C2H2 domain orders of rhesus homologous gene resembles human ZNF138. We proposed they represent the ancestral state. Through exon level alignment we know insertion/deletion (indel) induced protein truncation or peculiar splicing events lead to domain deletion of zf-C2H2 domain in orangutan lineage or gibbon lineage. The gibbon homologous gene and rhesus homologous gene both are not annotated with KRAB domain. There is a gap on the upstream region of gibbon orthologous gene which is homologous to human ZNF138 KRAB domain coding exon. We could not judge whether gibbon homologous gene does have one KRAB coding exon or not. Whereas such one KRAB coding exon is not found in the upstream region of rhesus homologous gene. Thus rhesus homologous gene experienced its lineage specific deletion. The orangutan homologous gene of human ZNF138 is manually predicted. The rhesus homologous gene of human ZNF138, ENSMMUG00000013327, is not ending with a stop codon in its coding sequence from Ensembl version 93.   Phenotype Association GWAS Studies NA   Functional Genomics Transcriptome Profile Proteomic Profile NA   Cross reference Phylostratigraphy ProteinHistorian Literature

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