Basic Information Ensembl ID ENSG00000198633        Symbol ZNF534 Description zinc finger protein 534 [Source:HGNC Symbol;Acc:26337] Status KNOWN Biotype protein_coding   Origination Transcript ENST00000301085 (branch 9)ENST00000433050 (branch 9)ENST00000332323 (branch 9)ENST00000432303 (branch 9) Peptide ENSP00000301085 Location chr19:52932440-52955568    Branch 9 Branch View Paralogues Gene ENSG00000167555 (ZNF528) Origination Type DNA level Duplication Paralogous Alignment ? Alignment Details Focal Gene Fraction Paralogues Gene Fraction E-value Bit Score Identity 90.9% 100% 0.0 856 64.39%   Selection Population Genomics Analysis Transcript Observed # of Nonsynonymous Substitution Observed # of Synonymous Substitution   q   ENST00000433050 54 15 0.32 Orthologous Evolutionary Estimation ? N S Ka Ks ω p q 1207.9 376.1 0.09 0.059 1.452 1.41E-01 8.99E-03 Domian Evolution The human gene encodes a protein containing one KRAB domain and sixteen zf-C2H2 domains. Domain order of chimpanzee homologous gene and gibbon orthologous gene resembles human gene, while rhesus homologous gene differs. We could not infer the ancestral state. Either loss of sequences in rhesus lineage or gain of sequences in the common ancestral lineage of human, chimpanzee and gibbon could be an explanation. The rhesus homologous gene of human ZNF534, ENSMMUG00000028720 is manually re-annotated since one homologous exon is not annotated in original gene structure.   Phenotype Association GWAS Studies   Functional Genomics Transcriptome Profile Proteomic Profile NA   Cross reference Phylostratigraphy ProteinHistorian Literature

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