Basic Information Ensembl ID ENSG00000256229        Symbol ZNF486 Description zinc finger protein 486 [Source:HGNC Symbol;Acc:20807] Status KNOWN Biotype protein_coding   Origination Transcript ENST00000597083 (branch 8)ENST00000335117 (branch 10) Peptide ENSP00000469306 Location chr19:20278037-20299585    Branch 8 (patchy_tree) ? Branch View Paralogues Gene ENSG00000237440 (ZNF737) Origination Type DNA level Duplication Paralogous Alignment ? Alignment Details Focal Gene Fraction Paralogues Gene Fraction E-value Bit Score Identity 97.6% 84.3% 0.0 731 75.00%   Selection Population Genomics Analysis Domian Evolution The human gene encodes a protein containing one KRAB domain and eleven zf-C2H2 domains. Domain order of chimpanzee homologous gene, orangutan homologous gene and gibbon orthologous gene resembles human gene, while rhesus homologous gene differs. We could not infer the ancestral state. Either gain of sequences in rhesus lineage or loss of sequences in the common ancestral lineage of human, chimpanzee, orangutan and gibbon could be an explanation.   Phenotype Association GWAS Studies NA   Functional Genomics Transcriptome Profile Proteomic Profile NA   Cross reference Phylostratigraphy NA ProteinHistorian NA Literature Description Branch Literature catarrhine 9 Jacobs et al., 2014

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